As the human species adapts to a synthetic environment, the body undergoes new transformations and mutations. With his partner Caprice, Saul Tenser - celebrity performance artist - publicly showcases the metamorphosis of his organs in avant-garde performances. Timlin, a National Organ Registry investigator, obsessively tracks them. Cronenberg returns to the body horror genre that he defined with his debut Scanners. The film premiered in the main competition at Cannes.